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Chemical Structure : PI3Kα-IN-5
Catalog No.: PC-62838Not For Human Use, Lab Use Only.
PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ.
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PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ; displays high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration; shows good inhibition of tumour growth (86% tumour growth inhibition at 50 mg/kg twice daily orally) in the MCF7 xenograft model in mice.
| M.Wt | 363.385 | |
| Formula | C17H17N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barlaam B, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):3030-3035.
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