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Chemical Structure : PIK-90
CAS No.: 677338-12-4
Catalog No.: PC-42844Not For Human Use, Lab Use Only.
PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
PIK-90 inhibits phosphorylation of Akt and S6, blocks the antiapoptotic protein Survivin and driving cell death in malignant glioma the clinical CDK1/2 inhibitor cooperated with roscovitine.
| M.Wt | 351.3593 | |
| Formula | C18H17N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 1 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)- |
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1. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
2. Niedermeier M, et al. Blood. 2009 May 28;113(22):5549-57.
3. Knight ZA, et al. Cell. 2006 May 19;125(4):733-47.
4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.
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