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Chemical Structure : PK68
CAS No.: 2173556-69-7
Catalog No.: PC-73017Not For Human Use, Lab Use Only.
PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $558 | In stock | |
| 100 mg | $1380 | In stock | |
| 1 g | Get quote |
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PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively).
PK68 blocks cellular activation of RIPK1, RIPK3, and MLKL upon necroptotic stimuli.
PK68 is a type II inhibitor of RIP1 kinase, highly selective inhibitor of RIPK1 kinase activity with IC50 of 90 nM, does not affect RIPK3 kinase activity at 1 uM, also demonstrated a reasonable selectivity against a panel of 369 kinases.
PK68 exhibits a favorable pharmacokinetic profile and no obvious toxicity in mice.
PK68 ameliorates TNF-induced systemic inflammatory response syndrome, and displays preventive suppression of tumor metastasis in the mouse cancer models.
| M.Wt | 424.519 | |
| Formula | C22H24N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate |
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1. Hou J, et al. Cell Death Dis. 2019 Jun 24;10(7):493.
2. Li Z, et al. Eur J Med Chem. 2022 Jan 15;228:114036.
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