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Chemical Structure : PKCiota-IN-49
CAS No.: 2230055-52-2
Catalog No.: PC-63489Not For Human Use, Lab Use Only.
PKCiota-IN-49 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM, >20-fold selectivity over PKC-α (IC50=71 nM) and PKC-β (IC50=350 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $368 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote |
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PKCiota-IN-49 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.8 nM, >20-fold selectivity over PKC-α (IC50=71 nM) and PKC-β (IC50=350 nM).
PKCiota-IN-49 inhibits PKC-ι on the phosphorylation of substrate ECT2 in HCCLM3 cells with IC50 of 3.0 uM.
| M.Wt | 395.466 | |
| Formula | C24H21N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline |
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1. Kwiatkowski J, et al. J Med Chem. 2018 May 4. doi: 10.1021/acs.jmedchem.8b00060.
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