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PLK1 inhibitor 31

Chemical Structure : PLK1 inhibitor 31

CAS No.: 2622273-55-4

PLK1 inhibitor 31 (PLK1-IN-4)

Catalog No.: PC-25788Not For Human Use, Lab Use Only.

PLK1 inhibitor 31 is a highly potent, selective polo-like kinase 1 (PLK1) inhibitor with IC50 of <0.5 nM, shows potent antiproliferative activity against a variety of cancer cell lines with IC50 of 11.1 nM for HCC cell line HepG2.

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Purity & Documentation Purity: 99.45% (HPLC) Select Batch:

Biological Activity

PLK1 inhibitor 31 is a highly potent, selective polo-like kinase 1 (PLK1) inhibitor with IC50 of <0.5 nM, shows potent antiproliferative activity against a variety of cancer cell lines with IC50 of 11.1 nM for HCC cell line HepG2.

Physicochemical Properties

M.Wt 550.56
Formula C24H25F3N6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)thiophene-2-carboxylate

References

1. Zhou Deng, et al. Eur J Med Chem. 2020 Nov 15:206:112697.

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