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PLpro-IN-6

Chemical Structure : PLpro-IN-6

CAS No.: 1093070-14-4

PLpro-IN-6 (SARS-CoV PLpro-IN-6)

Catalog No.: PC-45340Not For Human Use, Lab Use Only.

PLpro-IN-6 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 2.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PLpro-IN-6 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 2.6 uM.
PLpro-IN-6 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 13.1 uM, has no associated cytotoxicity and no inhibition for host DUBs.

Physicochemical Properties

M.Wt 346.4223
Formula C22H22N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 42 mg/mL

Chemical Name/SMILES

Benzamide, 5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-

References

1. Ratia K, et al. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.

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