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Chemical Structure : PMX205
CAS No.: 514814-49-4
Catalog No.: PC-38845Not For Human Use, Lab Use Only.
PMX205 is a potent, selective C5a receptor peptide antagonist with IC50 of 30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PMX205 is a potent, selective C5a receptor peptide antagonist with IC50 of 30 nM.
PMX205 significantly prevented DSS-induced colon inflammation in both regimens, associated with lower pro-inflammatory cytokine production and nitrotyrosine staining in colon sections.
PMX205 is efficacious in preventing DSS-induced colitis increased the levels of anti-inflammatory cytokines IL-4 and IL-10, and was efficacious in preventing DSS-induced colitis.
| M.Wt | 839.05 | |
| Formula | C45H62N10O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
cyclo[N2-(1-Oxo-3-Pheylpropyl)-Orn-Pro-D-Cha-Trp-Arg] |
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1. Woodruff TM, et al. J Pharmacol Exp Ther. 2005 Aug;314(2):811-7.
2. Jain U, et al. Br J Pharmacol. 2013 Jan;168(2):488-501.
3. Ager RR, et al. J Neurochem. 2010 Apr;113(2):389-401.
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