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Chemical Structure : PNU-120596
CAS No.: 501925-31-1
Catalog No.: PC-42901Not For Human Use, Lab Use Only.
PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $105 | In stock | |
| 50 mg | $175 | In stock | |
| 100 mg | $295 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs.
PNU-120596 increases the channel mean open time of α7 nAChRs but has no effect on ion selectivity and little to no effect on unitary conductance.
PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in pyramidal neurons.
PNU-120596 improves the auditory gating deficit caused by amphetamine, a model of schizophrenia.
| M.Wt | 311.7209 | |
| Formula | C13H14ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)- |
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1. Hurst RS, et al. J Neurosci. 2005 Apr 27;25(17):4396-405.
2. Dickinson JA, et al. J Neurochem. 2007 Feb;100(4):1089-96.
3. Grønlien JH, et al. Mol Pharmacol. 2007 Sep;72(3):715-24.
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