POL6014 | Neutrophil elastase inhibitor

Chemical Structure : POL6014

CAS No.: 906547-89-5

POL6014 (Lonodelestat, POL-6014)

Catalog No.: PC-25806Not For Human Use, Lab Use Only.

POL6014 (Lonodelestat, POL-6014) is a potent, selective, reversible and orally inhaled neutrophil elastase (NE) inhibitor, shows potential for cystic fibrosis (CF).

Packing	Price	Stock
5 mg	$218	In stock
10 mg	$358	In stock
25 mg	$558	In stock
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Biological Activity

POL6014 (Lonodelestat, POL-6014) is a potent, selective, reversible and orally inhaled neutrophil elastase (NE) inhibitor, shows potential for cystic fibrosis (CF).

Physicochemical Properties

M.Wt	1478.76
Formula	C71H111N15O19
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclo[L-alanyl-L-seryl-L-isoleucyl-L-prolyl-L-prolyl-L-glutaminyl-L-lysyl-L-tyrosyl-D-prolyl-L-prolyl-(2S)-2-aminodecanoyl-L-α-glutamyl-L-threonyl]

References

1. Barth P, et al. J Cyst Fibros. 2020 Mar;19(2):299-304.

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POL6014 (Lonodelestat, POL-6014)

Biological Activity

Physicochemical Properties

References

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