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Chemical Structure : PP 242
CAS No.: 1092351-67-1
Catalog No.: PC-42608Not For Human Use, Lab Use Only.
Torkinib (PP242) is a potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Torkinib (PP242) is a potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.
Torkinib (PP242) shows no activity against PKC-β, RET, or JAK2 but inhibits PKC-α (IC50=50 nM).
Torkinib (PP242) blocks the phosphorylation of Akt at S473 and prevents its full activation, inhibits proliferation of primary cells more completely than rapamycin.
| M.Wt | 308.3378 | |
| Formula | C16H16N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indol-5-ol, 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]- |
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1. Janes MR, et al. Nat Med. 2010 Feb;16(2):205-13.
2. Feldman ME, et al. PLoS Biol. 2009 Feb 10;7(2):e38.
3. Hoang B, et al. J Biol Chem. 2012 Jun 22;287(26):21796-805.
4. Hsieh AC, et al. Cancer Cell. 2010 Mar 16;17(3):249-61.
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