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Chemical Structure : PPTN
Catalog No.: PC-35050Not For Human Use, Lab Use Only.
PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.
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PPTN is a potent, highly specific antagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays.
PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM.
PPTN inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.
| M.Wt | 475.511 | |
| Formula | C29H24F3NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168.
2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68.
3. Kiselev E, et al. ACS Chem Biol. 2014 Dec 19;9(12):2833-42.
4. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9.
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