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PQR-530

Chemical Structure : PQR-530

CAS No.: 1927857-61-1

PQR-530 (PQR530, PQR 530)

Catalog No.: PC-35552Not For Human Use, Lab Use Only.

PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively.
PQR-530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.

Physicochemical Properties

M.Wt 407.42
Formula C18H23F2N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine

References

1. Brandt C, et al. Neuropharmacology. 2018 Aug 3;140:107-120.

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