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Chemical Structure : PRT062607
Catalog No.: PC-22081Not For Human Use, Lab Use Only.
PRT062607 (P505-15) is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.
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PRT062607 (P505-15) is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons.
PRT062607 displays 80-fold greater than its affinity for other kinases.
PRT062607 potently inhibit SYK- and BCR-dependent activation of normal B-cells.
PRT062607 successfully inhibits SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL.
PRT062607 prevents BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model.
| M.Wt | 393.46 | |
| Formula | C19H23N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Spurgeon SE, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87.
2. Rasool S, et al. Sci Rep. 2024 Apr 2;14(1):7739.
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