PSB-2014 | P2X1 antagonist | Probechem Biochemicals

Chemical Structure : PSB-2014

PSB-2014 (PSB2014)

Catalog No.: PC-26166Not For Human Use, Lab Use Only.

PSB-2014 is a potent, selective and competitive P2X1 receptor (P2X1R) with IC50 of 23.1 nM, weakly inhibits P2X4, P2X7 and shows no activity against P2X2, P2X3 receptors.

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Biological Activity

PSB-2014 is a potent, selective and competitive P2X1 receptor (P2X1R) with IC50 of 23.1 nM, weakly inhibits P2X4, P2X7 and shows no activity against P2X2, P2X3 receptors.

Physicochemical Properties

M.Wt	383.67
Formula	C15H8ClF6NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-bis(trifluoromethyl)phenyl)-4-chloro-2-hydroxybenzamide

References

1. Maoqun Tian, et al. J Med Chem. 2020 Jun 11;63(11):6164-6178.

2. Christa E Müller, et al. Recommended tool compounds and drugs for blocking P2X and P2Y receptors. Purinergic Signal. 2021 Dec;17(4):633-648.

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PSB-2014 (PSB2014)

Biological Activity

Physicochemical Properties

References

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