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Chemical Structure : PSB-CB-27
Catalog No.: PC-49029Not For Human Use, Lab Use Only.
PSB-CB-27 is a potent, selective antagonist of GPR18 with IC50 of 650 nM, shows no inhibition on GPR55 and low affinity for CB1/CB2 receptors.
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PSB-CB-27 is a potent, selective antagonist of GPR18 with IC50 of 650 nM, shows no inhibition on GPR55 and low affinity for CB1/CB2 receptors.
PSB-CB-27 showed improved selectivity versus CB receptors as compared to PSB-CB5.
PSB-CB-27 shows a complete blockade of THC-induced GPR18 activation and is thus a superior tool for target validation, compared with partial inhibition by PSB-CB5.
PSB-CB-27 exhibits a pIC50 of 6.2 at the hGPR18 in the β-arrestin recruitment assays.
| M.Wt | 471.012 | |
| Formula | C25H27ClN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schoeder CT, et al. Eur J Med Chem. 2018 Jul 15;155:381-397.
2. Kozłowska H, et al. Int J Mol Sci. 2022 Jan 26;23(3):1427.
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