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Chemical Structure : PSTC
Catalog No.: PC-60630Not For Human Use, Lab Use Only.
A novel potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity).
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A novel potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity); induces Nrf2 nuclear translocation, Nrf2-regulated gene expression, and downstream signaling events, including induction of NAD(P)H:NQO1 enzyme activity and heme oxygenase-1 protein expression, in an Nrf2-dependent manner, does not inhibit IL-1β-inducedNF-κB translocation or insulin-induced S6 phosphorylation in human cells; restores oxidant (tert-butyl hydroperoxide)-induced glutathione depletion in vitro and in vivo models of pulmonary oxidative stress.
| M.Wt | 355.287 | |
| Formula | C15H8F3NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yonchuk JG, et al. J Pharmacol Exp Ther. 2017 Aug 8. pii: jpet.117.241794.
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