PTK7/β-catenin inhibitor 01065

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Chemical Structure : PTK7/β-catenin inhibitor 01065

CAS No.: 906147-24-8

Catalog No.: PC-38652Not For Human Use, Lab Use Only.

PTK7/β-catenin inhibitor 01065 is a small molecule inhibitor of PTK7/β-catenin interaction (IC50=8.9 uM) targeting the Wnt pathway signaling, induces antiproliferative and antitumor effects in vitro in CRC cells harboring β-catenin or adenomatous polyposis coli (APC) mutations.

Packing	Price	Stock
5 mg	$358	In stock
10 mg	$548	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PTK7/β-catenin inhibitor 01065 is a small molecule inhibitor of PTK7/β-catenin interaction (IC50=8.9 uM) targeting the Wnt pathway signaling, induces antiproliferative and antitumor effects in vitro in CRC cells harboring β-catenin or adenomatous polyposis coli (APC) mutations.

Physicochemical Properties

M.Wt	340.382
Formula	C22H16N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-([1,1'-biphenyl]-2-yl)-2-(1H-indol-3-yl)-2-oxoacetamide

References

1. Ganier L, et al. ACS Chem Biol. 2022 Apr 28. doi: 10.1021/acschembio.1c00826.

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