Catalog No.: PC-26600Not For Human Use, Lab Use Only.
PU-48 is a selective inhibitor of urea transporters UT-A and UT-B with IC50 of 0.32 uM (UT-A1), inhibits UT-B-facilitated urea transport with IC50 of 0.21 uM, 0.21 in human, 0.33 uM in rat, and 2.1 uM for human, rat, and mouse.
PU-48 is a selective inhibitor of urea transportersUT-A and UT-B with IC50 of 0.32 uM (UT-A1), inhibits UT-B-facilitated urea transport with IC50 of 0.21 uM, 0.21 in human, 0.33 uM in rat, and 2.1 uM for human, rat, and mouse.
PU-48 does not affect non-UT-B-mediated transmembrane urea transport in erythrocytes.
PU-48 inhibits urea transport in rat terminal inner medullary collecting ducts (IMCDs).
PU-48 (100 mg/kg) significantly increased urea excretion in both wild-type mice and UT-B-null mice, did not change blood Na+, K+, or Cl− levels or nonurea solute excretion in rats and mice.
