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Chemical Structure : PU-H71
CAS No.: 873436-91-0
Catalog No.: PC-72710Not For Human Use, Lab Use Only.
PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells.
PU-H71 inhibits cell growth in a range of breast cancer cell lines with IC50 values of 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells, respectively.
PU-H71 inhibits cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
PU-H71 demonstrated anti-lymphoma activity and showed synergistic effect with dual PI3K/mTOR inhibition in vitro and in vivo.
| M.Wt | 512.37 | |
| Formula | C18H21IN6O2S | |
| Appearance | Solid | |
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| Solubility |
100 mM in DMSO (51.2 mg/mL) |
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1. Huazhong He, et al. J Med Chem. 2006 Jan 12;49(1):381-90.
2. Eloisi Caldas-Lopes, et al. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73.
3. Carmel T Chan, et al. Cancer Res. 2008 Jan 1;68(1):216-26.
4. Giulino-Roth L, et al. Mol Cancer Ther. 2017 Sep;16(9):1779-1790.
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