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Chemical Structure : Palbociclib hydrochloride
CAS No.: 827022-32-2
Catalog No.: PC-45863Not For Human Use, Lab Use Only.
A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $56 | In stock | |
| 50 mg | $80 | In stock | |
| 100 mg | $104 | In stock | |
| 200 mg | Get quote |
Bulk size, bulk discount!
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A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM; shows antiproliferative effect against retinoblastoma (Rb)-positive tumor cells in vitro and reduces the phospho-Ser780/Ser795 on the Rb protein; orally bioavailable.
Breast Cancer
Approved
| M.Wt | 483.9937 | |
| Formula | C24H30ClN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6 mg/mL (Need ultrasonic or warming) |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, hydrochloride (1:1) |
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1. Toogood PL, et al. J Med Chem. 2005 Apr 7;48(7):2388-406.
2. Fry DW, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.
3. Baughn LB, et al. Cancer Res. 2006 Aug 1;66(15):7661-7.
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