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Chemical Structure : Paltusotine
CAS No.: 2172870-89-0
Catalog No.: PC-38007Not For Human Use, Lab Use Only.
Paltusotine (CRN00808) is an orally bioavailable, nonpeptide, somatostatin receptor subtype 2 (SST2) agonist with EC50 of 0.25 nM.
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| 25 mg | $598 | In stock | |
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Paltusotine (CRN00808) is an orally bioavailable, nonpeptide, somatostatin receptor subtype 2 (SST2) agonist with EC50 of 0.25 nM.
Paltusotine is >4000-fold selective for SST2 over other somatostatin receptor subtypes.
Paltusotine suppresses stimulated-GH and IGF-1 secretion in rats. Paltusotine suppresses GH and IGF-1 in a dose-dependent fashion, with a safety profile similar to currently approved SST2 receptor ligands.
Paltusotine is a promising once-daily oral nonpeptide SST2 agonist candidate for managing acromegaly and neuroendocrine tumors.
| M.Wt | 456.497 | |
| Formula | C27H22F2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl)-2-hydroxybenzonitrile |
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1. Gadelha MR, et al. J Clin Endocrinol Metab. 2022 Jan 18;107(2):297-308.
2. Madan A, et al. Pituitary. 2022 Apr;25(2):328-339.
3. Betz SF, et al. Endocrine Rev. 2018;39(2):i1-i1417.
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