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Chemical Structure : Pamapimod
CAS No.: 449811-01-2
Catalog No.: PC-42565Not For Human Use, Lab Use Only.
Pamapimod (Ro4402257; R1503) is a potent, selective, orally bioavailable p38α MAPK inhibitor with Kd of 0.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Pamapimod (Ro4402257; R1503) is a potent, selective, orally bioavailable p38α MAPK inhibitor with Kd of 0.2 nM.
Pamapimod (Ro4402257; R1503) displays >100 fold selectivity over p38β (Kd=29 nM), and no affinity against p38γ, p38δ and a broad panel of kianses.
Pamapimod (Ro4402257; R1503) inhibits LPS-stimulated TNF-alpha production by monocytes, IL-1beta production in human whole blood.
Pamapimod (Ro4402257; R1503) exhibits the ability to inhibit the signs and symptoms of RA and other autoimmune diseases.
| M.Wt | 406.3833 | |
| Formula | C19H20F2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,4-difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methyl- |
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1. Goldstein DM, et al. J Med Chem. 2011 Apr 14;54(7):2255-65.
2. Hill RJ, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):610-9.
3. Cohen SB, et al. Arthritis Rheum. 2009 Feb;60(2):335-44.
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