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Pandacostat

Chemical Structure : Pandacostat

CAS No.: 1224158-00-2

Pandacostat

Catalog No.: PC-62239Not For Human Use, Lab Use Only.

Pandacostat is the first nonselective HDAC inhibitor (pan-HDACi) with Ki of 0.12/0.07/0.95/0.18/0.032/1.1/0.5/1.4 uM for HDAC1/2/3/4/5/6/7/8/9, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pandacostat is the first nonselective HDAC inhibitor (pan-HDACi) with Ki of 0.12/0.07/0.95/0.18/0.032/1.1/0.5/1.4 uM for HDAC1/2/3/4/5/6/7/8/9, respectively.
    Pandacostat exhibts activity in biochemical and cellular assay systems.

    Physicochemical Properties

    M.Wt 357.322
    Formula C17H15N3O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-3-[4-[[[(E)-(2,3-dihydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]amino]carbamoyl]phenyl]-N-hydroxyprop-2-enamide

    References

    1. Bradner JE, et al. Nat Chem Biol. 2010 Mar;6(3):238-243.

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