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Parthenolide

Chemical Structure : Parthenolide

CAS No.: 20554-84-1

Parthenolide

Catalog No.: PC-25411Not For Human Use, Lab Use Only.

Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs.

Physicochemical Properties

M.Wt 248.32
Formula C15H20O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3aS,9aR,10aR,10bS,E)-6,9a-Dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one

References

1. Zhao WS, et al. Acta Pharmacol Sin. 2023 Aug;44(8):1701-1711.

2. Nakshatri H, et al. Cell Death Dis. 2015 Jan 22;6:e1608.

3. Zhao X, et al. J Exp Clin Cancer Res. 2014 Jan 6;33:3.

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