Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Antibiotics and Antivirals-Parasite-PfDHFR inhibitor P218
PfDHFR inhibitor P218

Chemical Structure : PfDHFR inhibitor P218

CAS No.: 1142407-81-5

Add to Favorites

PfDHFR inhibitor P218

Catalog No.: PC-26679Not For Human Use, Lab Use Only.

PfDHFR inhibitor P218 is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PfDHFR inhibitor P218 is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM.

Physicochemical Properties

M.Wt 360.41
Formula C18H24N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-(3-((2,4-diamino-6-ethylpyrimidin-5-yl)oxy)propoxy)phenyl)propanoic acid

References

1. Decharuangsilp S, et al. Eur J Med Chem. 2026 Apr 19;313:118863.

2. Yuthavong Y, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: