Catalog No.: PC-28297Not For Human Use, Lab Use Only.
PhSAN is a selective small-molecule inhibitor of E3 ubiquitin ligase RNF25 (ITC KD=1.57 uM), suppresses RNF25 ubiquitin ligase activity and induces ER stress, induces PANoptosis.
PhSAN is a selective small-molecule inhibitor of E3 ubiquitin ligase RNF25 (ITC KD=1.57 uM), suppresses RNF25 ubiquitin ligase activity and induces ER stress, induces PANoptosis.
PhSAN activates ER stress by impairing RNF25-dependent ubiquitination and degradation of eEF1A.
PhSAN accelerates ER stress to trigger PANoptosis.
PhSAN cooperates with bortezomib to potentiate PANoptosis and antitumor efficacy in renal cell carcinoma (RCC).
Physicochemical Properties
M.Wt
193.22
Formula
C9H7NO2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3-(phenylsulfonyl)acrylonitrile
References
1. Kang J, et al. Cell Insight. 2026 Aug 7;5(5):100353.
