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Chemical Structure : Phox-I2
CAS No.: 353495-22-4
Catalog No.: PC-49776Not For Human Use, Lab Use Only.
Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox.
Phox-I2 is active in suppressing ROS production in both human and murine neutrophils.
Phox-I2 is effective in inhibiting NOX2-mediated superoxide production dose-dependently in human and murine neutrophils without detectable toxicity.
Phox-I2 inhibitedcollagen-induced platelet aggregation without affecting the tail bleeding time, inhibited in vivo platelet adhesion/accumulation at the laser injury sites on the saphenous vein without affecting the time for complete cessation of blood loss.
| M.Wt | 337.34 | |
| Formula | C18H15N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3a,4,5,9b-Tetrahydro-8-nitro-4-(3-nitrophenyl)-3H-cyclopenta[c]quinoline |
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1. Emily E Bosco, et al. Chem Biol. 2012 Feb 24;19(2):228-42.
2. H Akbar, et al. J Thromb Haemost. 2018 Oct;16(10):2083-2096.
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