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Chemical Structure : Pico145
CAS No.: 1628287-16-0
Catalog No.: PC-60846Not For Human Use, Lab Use Only.
Pico145 is a highly potent, subtype-selective TRPC1/4/5 channels inhibitor with potency ranged from 9 to 1300 pM, depending on the TRPC1/4/5 subtype and activation mechanism.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Pico145 (HC-608) is a highly potent, subtype-selective TRPC1/4/5 channels inhibitor with potency ranged from 9 to 1300 pM, depending on the TRPC1/4/5 subtype and activation mechanism.
Pico145 shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8, and store-operated Ca2+ entry mediated by Orai1.
Pico145 prevents Ca2+ entry through TRPC5-TRPC1 and TRPC4-TRPC1 with IC50 of 0.199 and 0.033 nM, respectively.
Pico145 inhibits S1P-activated TRPC4 channels at −100 and +100 mV with IC50 of 0.012 and 0.03 nM, respectively.
Pico145 strongly inhibits Icat and EA-induced cytotoxicity in synovial sarcoma cells.
| M.Wt | 524.881 | |
| Formula | C23H20ClF3N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(4-chlorobenzyl)-1-(3-hydroxypropyl)-3-methyl-8-(3-(trifluoromethoxy)phenoxy)-3,7-dihydro-1H-purine-2,6-dione |
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1. Rubaiy HN, et al. J Biol Chem. 2017 May 19;292(20):8158-8173.
2. Rubaiy HN, et al. Channels (Austin). 2017 Sep 3;11(5):362-364.
3. Muraki K, et al. Sci Rep. 2017 Dec 5;7(1):16988.
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