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Chemical Structure : Poloppin II
Catalog No.: PC-61201Not For Human Use, Lab Use Only.
Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest.
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Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest。
Poloppin II is also active against PLK2 PDB with an IC50 of 105 uM in FP assay, engages PLK1 and PLK4, sensitizes cells expressing mutant KRAS by approximately 5-fold。
Poloppin II demonstrates effectivity gainst KRAS-expressing cancer xenografts.
| M.Wt | 511.973 | |
| Formula | C28H25ClF3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Narvaez AJ, et al. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7.
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