Polyphyllin I

Chemical Structure : Polyphyllin I

CAS No.: 50773-41-6

Catalog No.: PC-27528Not For Human Use, Lab Use Only.

Polyphyllin I is a steroidal saponin isolated from Paris polyphylla with broad and strong anticancer effect, induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal, inhibits PI3K kinase with IC50 of 0.84 uM.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$118	In stock
50 mg	$188	In stock
100 mg	$288	In stock
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Biological Activity

Polyphyllin I is a steroidal saponin isolated from Paris polyphylla with broad and strong anticancer effect, induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal, inhibits PI3K kinase with IC50 of 0.84 uM.
Polyphyllin I ameliorates gefitinib resistance and inhibits the VEGF/VEGFR2/p38 pathway by targeting HIF-1a in lung adenocarcinoma.
Polyphyllin I shows potent cytotoxicity on AML cells MOLM-13 with IC50 of 0.44 uM.
Polyphyllin I causes ferroptosis via the accumulation of intracellular iron concentration and triggering lipid peroxidation.
Polyphyllin I significantly inhibited tumor progression and prolonged mouse survival at 4 mg/kg with well tolerance in acute myeloid leukemia (AML).

Physicochemical Properties

M.Wt	855.03
Formula	C44H70O16
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-(((2S,3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4-hydroxy-6-(hydroxymethyl)-2-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

References

1. Zhou X, et al. Phytomedicine. 2026 Jan;150:157658.

2. Zhou X, et al. J Nat Med. 2024 Jun;78(3):618-632.

3. He J, et al. Biomed Pharmacother. 2019 Sep;117:109189.

Polyphyllin I

Biological Activity

Physicochemical Properties

References

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