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Chemical Structure : Pomotrelvir
Catalog No.: PC-21248Not For Human Use, Lab Use Only.
Pomotrelvir (PBI-0451) is a potent competitive inhibitor of SARS-CoV-2 Mpro (Ki=2.7 nM) with high selectivity against human proteases, inhibits wild-type SARS-CoV-2 Mpro with IC50 of 24 nM.
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Pomotrelvir (PBI-0451) is a potent competitive inhibitor of SARS-CoV-2 Mpro (Ki=2.7 nM) with high selectivity against human proteases, inhibits wild-type SARS-CoV-2 Mpro with IC50 of 24 nM.
Pomotrelvir (PBI-0451) inhibits P132H variant, which is commonly observed in Omicron isolates and has been shown to have no effect on nirmatrelvir inhibition.
Pomotrelvir (PBI-0451) shows broad-spectrum activity against Mpro enzymes from other pathogenic and common cold CoV strains with IC50 ranging from 61 to 379 nM.
Pomotrelvir (PBI-0451) exhibits high selectivity against host proteases.
Pomotrelvir inhibits SARS-CoV-2 with EC50 ofof 32 nM (by plaque assay) and 36 nM (by qRT-PCR) in the SARS CoV-2 assay in iPS-AT2 cells and 23 nM in the SARS-CoV-2 NLuc assay, respectively.
| M.Wt | 455.94 | |
| Formula | C23H26ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xiao Tong, et al. Antimicrob Agents Chemother. 2023 Oct 6:e0084023.
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