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Chemical Structure : Pomstafib-2
Catalog No.: PC-61169Not For Human Use, Lab Use Only.
Pomstafib-2 is the pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.
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Pomstafib-2 is the pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.
Pomstafib-2 decreases the phosphorylation at STAT5b Tyr699 with IC50 of 1.5 uM in STAT5b-GFP-transfected K562 cells in human leukaemia cells and induces apoptosis in a STAT5-dependent manner.
Pomstafib-2 shows high selectivity for STAT5b over STAT5a.
| M.Wt | 1101.042 | |
| Formula | C52H66N2O20P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.
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