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Chemical Structure : Ponesimod
CAS No.: 854107-55-4
Catalog No.: PC-42656Not For Human Use, Lab Use Only.
Ponesimod (ACT-128800) is a potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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Ponesimod (ACT-128800) is a potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM.
Ponesimod (ACT-128800) shows weak activity on S1P3 (EC50=123 nM).
Ponesimod (ACT-128800) activates S1P1-mediated signal transduction with high potency (EC50 of 5.7 nM).
Ponesimod (ACT-128800) causes maximal reduction of circulating lymphocytes at a dose of 3 mg/kg.
| M.Wt | 460.9736 | |
| Formula | C23H25ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- |
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1. Bolli MH, et al. J Med Chem. 2010 May 27;53(10):4198-211.
2. Piali L, et al. J Pharmacol Exp Ther. 2011 May;337(2):547-56.
3. Sobel K, et al. J Biol Chem. 2013 May 24;288(21):14839-51.
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