Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PptT inhibitor 8918
Catalog No.: PC-36063Not For Human Use, Lab Use Only.
PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PptT inhibitor 8918 (Compound 8918) is a mycobactericidal amidino-urea compound that targets phosphopantetheinyl transferase (PptT, IC50=2.5 uM), shows an MIC90 of 3.1 uM against Mtb H37Rv; also exhibits MIC90s ranged from 0.56-3.0 uM (median 1.5 uM) against 29 clinical isolates of Mtb; inhibits growth of WT Mtb, but not of the pptT mutant W170S or WT Mtb expressing the pptT W170S mutant; kills Mycobacterium tuberculosis (Mtb) by binding and partially inhibiting PptT.
| M.Wt | 262.357 | |
| Formula | C14H22N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Ballinger E, et al. Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
