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Chemical Structure : Preladenant
CAS No.: 377727-87-2
Catalog No.: PC-42729Not For Human Use, Lab Use Only.
Preladenant (SCH420814) is a potent and highly selective adenosine A2A receptor competitive antagonist with Ki of 1.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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Preladenant (SCH420814) is a potent and highly selective adenosine A2A receptor competitive antagonist with Ki of 1.1 nM.
Preladenant (SCH420814) has >1000-fold selectivity over all other adenosine receptors.
Preladenant (SCH420814) attenuates hypolocomotion induced by the A2AR agonist CGS-21680.
Preladenant (SCH420814) potentiates L-Dopa -induced contralateral rotations after 6-hydroxydopamine lesions in the medial forebrain bundle in rats (0.1-1 mg/kg); orally active.
| M.Wt | 503.5563 | |
| Formula | C25H29N9O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]- |
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1. Neustadt BR, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):967-71.
2. Hodgson RA, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):294-303.
3. Hodgson RA, et al. Exp Neurol. 2010 Oct;225(2):384-90.
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