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Chemical Structure : Procaspase-3 activator 1541
Catalog No.: PC-62209Not For Human Use, Lab Use Only.
Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM).
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Procaspase-3 activator 1541 is a small-molecule inducer of cell death that noncovalently self-assembles into chemical fibrils and activates procaspase-3 and 6 in vitro (EC50=2.4 and 2.8 uM); does not activate procaspases-1 or -7, induces cell death by the fibrillar rather than the soluble form of the compound; induces extensive proteolysis including caspase substrates, yet modulatory profiling reveals that chemi-fibrils form a distinct class from existing inducers of cell death.
| M.Wt | 411.417 | |
| Formula | C24H17N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.
2. Zorn JA, et al. J Biol Chem. 2012 Sep 28;287(40):33781-95.
3. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.
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