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Procaspase-6 inhibitor 13

Chemical Structure : Procaspase-6 inhibitor 13

CAS No.: 1575392-45-8

Procaspase-6 inhibitor 13 (Procaspase-6-IN-13)

Catalog No.: PC-73051Not For Human Use, Lab Use Only.

Procaspase-6 inhibitor 13 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.38 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Procaspase-6 inhibitor 13 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.38 uM.
Procaspase-6 inhibitor 13 binds to pro-C6 at the dimer interface and contacts amino acids Y198, T199 and E214.
Procaspase-6 inhibitor 13 significantly stabilizes procaspase-6.

Physicochemical Properties

M.Wt 311.32
Formula C16H14FN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(((3-(5-aminopyrimidin-2-yl)pyridin-2-yl)amino)methyl)-5-fluorophenol

References

1. Jeremy Murray, et al. ChemMedChem. 2014 Jan;9(1):73-7, 2.

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