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Pterosin B

Chemical Structure : Pterosin B

CAS No.: 34175-96-7

Pterosin B ((2R)-Pterosin B)

Catalog No.: PC-63123Not For Human Use, Lab Use Only.

Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain; shows no effect on up-regulation of MEF2 and down-regulation of CRTC2 activities by SIK1 or SIK2; promotes glucose production by up-regulating gluconeogenic gene expression in mouse hepatoma AML-12 cells, decreases the glycogen content and stimulates an association between PHKG2 and SIK3.

Physicochemical Properties

M.Wt 218.296
Formula C14H18O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (R)-

References

1. Itoh Y, et al. J Biol Chem. 2015 Jul 17;290(29):17879-93.

2. Yahara Y, et al. Nat Commun. 2016 Mar 24;7:10959.

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