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Chemical Structure : Purfalcamine
Catalog No.: PC-62162Not For Human Use, Lab Use Only.
Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM.
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Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM; inhibits proliferation of P falciparum strains (Dd2, FCB, HB3 and W2) with nanomolar EC50s of (171–259 nM); blocks microneme discharge and erythrocyte invasion by P. falciparum merozoites; an anti-malaria parasite agent.
| M.Wt | 528.636 | |
| Formula | C29H33FN8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kato N, et al. Nat Chem Biol. 2008 Jun;4(6):347-56.
2. Bansal A, et al. J Biol Chem. 2013 Jan 18;288(3):1590-602.
3. Gaji RY, et al. Antimicrob Agents Chemother. 2014 May;58(5):2598-607.
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