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Chemical Structure : Purvalanol B
CAS No.: 212844-54-7
Catalog No.: PC-45446Not For Human Use, Lab Use Only.
A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $360 | In stock | |
| 250 mg | Get quote |
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A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively; no inhibition for cdk4/cyclin D1 (>10 uM); has no effect on Erk1, PKC, Raf, CK1, CK2.
| M.Wt | 432.9039 | |
| Formula | C20H25ClN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]- |
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1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.
2. Chang YT, et al. Chem Biol. 1999 Jun;6(6):361-75.
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