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Chemical Structure : Pyr10
CAS No.: 1315323-00-2
Catalog No.: PC-45632Not For Human Use, Lab Use Only.
Pyr10 is a novel TRPC3-selective inhibitor, inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with IC50 of 0.72 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $72 | In stock | |
| 50 mg | $288 | In stock |
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Pyr10 is a novel TRPC3-selective inhibitor, inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with IC50 of 0.72 uM.
Pyr10 displays substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.
| M.Wt | 449.3701 | |
| Formula | C18H13F6N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenesulfonamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl- |
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1. Schleifer H, et al. Br J Pharmacol. 2012 Dec;167(8):1712-22.
2. Alkhani H, et al. Mol Pain. 2014 Jun 26;10:43.
3. Chauvet S, et al. Front Pharmacol. 2016 Dec 12;7:486.
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