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Chemical Structure : Pyridoclax
CAS No.: 1651890-44-6
Catalog No.: PC-43096Not For Human Use, Lab Use Only.
Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.
Pyridoclax (MR29072) strongly sensitizes ovarian cancer chemoresistant IGROV1-R10 cells to Bcl-xL targeting siRNA and ABT-737, leading to massive apoptosis, can not induce cell death as single agents.
Pyridoclax (MR29072) induces ER stress and modifies Bcl-2 family expression, but its cytotoxic effect does not require these events.
| M.Wt | 426.5118 | |
| Formula | C29H22N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-3'-methyl-3''-styryl-3,2':5',2'':5'',3'''-quaterpyridine |
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1. Gloaguen C, et al. J Med Chem. 2015 Feb 26;58(4):1644-68.
2. Groo AC, et al. Eur J Pharm Sci. 2017 Jan 15;97:218-226.
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