Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.
Pyridoclax (MR29072) strongly sensitizes ovarian cancer chemoresistant IGROV1-R10 cells to Bcl-xL targeting siRNA and ABT-737, leading to massive apoptosis, can not induce cell death as single agents.
Pyridoclax (MR29072) induces ER stress and modifies Bcl-2 family expression, but its cytotoxic effect does not require these events.
