Catalog No.: PC-45409Not For Human Use, Lab Use Only.
Pyrimethamine (Pirimetamin, RP 4753) is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties, interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR, also is a potent NRF2 inhibitor.
Pyrimethamine (Pirimetamin, RP 4753) is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties, interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR, also is a potent NRF2 inhibitor.
Pyrimethamine has also been found to reduce the expression of SOD1.
Pyrimethamine also is a potent NRF2 inhibitor with IC50 of 1.23 uM, reduces NRF2 half-life by promoting NRF2 ubiquitination and degradation in KYSE70 and KYSE180 cells.
