Q151 | GuaB2 inhibitor | Probechem Biochemicals

Chemical Structure : Q151

Q151 (Mtb IMPDH2 inhibitor)

Catalog No.: PC-28182Not For Human Use, Lab Use Only.

Q151 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, MtbIMPDH2) with Ki app of 18 nM, does not inhibit human IMPDH2.

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Biological Activity

Q151 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, MtbIMPDH2) with Ki app of 18 nM, does not inhibit human IMPDH2.
Q151 shows antitubercular activity against Mtb H37Rv with MIC of 3.1 uM.

Physicochemical Properties

M.Wt	418.40
Formula	C23H16F2N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2-(4-cyanophenyl)benzo[d]oxazol-5-yl)-2-((2,3-difluorophenyl)amino)propanamide

References

1. Chacko S, et al. J Med Chem. 2018 Jun 14;61(11):4739-4756.

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Q151 (Mtb IMPDH2 inhibitor)

Biological Activity

Physicochemical Properties

References

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