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Chemical Structure : QD325
Catalog No.: PC-62575Not For Human Use, Lab Use Only.
QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM).
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QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM).
QD325 induces stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells.
QD325 dose-dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3, and HSPA5, blocks mitochondrial function by inhibiting mtDNA transcription and downregulating the mtDNA-encoded OXPHOS enzymes.
QD325 is well tolerated in vivo and significantly delayes tumor growth in mice.
| M.Wt | 327.343 | |
| Formula | C20H13N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kuang Y, et al. J Med Chem. 2018 Feb 22;61(4):1576-1594.
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