QGC583 | Aminopeptidase A inhibitor | Probechem Biochemicals

Chemical Structure : QGC583

QGC583 (QGC-583)

Catalog No.: PC-23036Not For Human Use, Lab Use Only.

QGC583 is a potent, selective aminopeptidase A (APA) with IC50 of 4 nM, >5000-fold selective over aminopeptidase N (APN).

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Biological Activity

QGC583 is a potent, selective aminopeptidase A (APA) with IC50 of 4 nM, >5000-fold selective over aminopeptidase N (APN).
QGC583 penetrates the brain and reach brain APA after i.v. administration in rats, but also strongly inhibits renal and cardiac APA activities.

Physicochemical Properties

M.Wt	271.25
Formula	C12H18NO4P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4R)-4-amino-4-(hydroxy(phenethyl)phosphoryl)butanoic acid

References

1. Balavoine F, et al. Bioorg Med Chem Lett. 2024 Sep 2:129940.

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QGC583 (QGC-583)

Biological Activity

Physicochemical Properties

References

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