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QO IIR

Chemical Structure : QO IIR

CAS No.: 150404-10-7

QO IIR

Catalog No.: PC-35901Not For Human Use, Lab Use Only.

QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM.

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Biological Activity

QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM; fully reverses the reserpine-induced catalepsy in vivo, demonstrates behavioural and neurochemical effects in reserpinized rats treated with LD/CD.

Physicochemical Properties

M.Wt 285.255
Formula C15H11NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(3,4-Dihydroxy-2-nitrophenyl)-1-phenyl-2-propen-1-one

References

1. Rivas E, et al. Br J Pharmacol. 1999 Apr;126(7):1667-73.

2. Pérez RA, et al. Biochem Pharmacol. 1993 May 25;45(10):1973-81.

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