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Chemical Structure : QS-11
CAS No.: 944328-88-5
Catalog No.: PC-70264Not For Human Use, Lab Use Only.
QS-11 (QS11) is a small molecule inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) with Kd of 620 nM, synergizes the Wnt/beta-catenin signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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QS-11 (QS11) is a small molecule inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) with Kd of 620 nM, synergizes the Wnt/beta-catenin signaling.
QS-11 synergizes with Wnt-3a in activating Wnt signaling through ARF activation (EC50=0.5 uM.
QS-11 increases levels of nuclear β-catenin and inhibits the migration of MDA-MB-231 cells with IC80 of 2.5 uM.
| M.Wt | 567.68 | |
| Formula | C36H33N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-((9-([1,1'-biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)-3-phenylpropan-1-ol |
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1. Zhang Q, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8.
2. Singh MK, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4838-42.
3. Ivanyuk D, et al. Cell Physiol Biochem. 2015;36(2):810-30.
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