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You are here:Home-Chemical Inhibitors & Agonists-TGF-beta/Smad-TGF beta Receptor (TGFBR)-QX03-46
QX03-46

Chemical Structure : QX03-46

CAS No.: 3051508-55-2

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QX03-46 (QX 03-46)

Catalog No.: PC-28052Not For Human Use, Lab Use Only.

QX03-46 is a first-in-class small-molecule inhibitor targeting connective tissue growth factor (CTGF), significantly disrupts the CTGF/TGF-β1 signaling axis and suppresses cancer-associated fibroblast (CAF) functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion in PDAC.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

QX03-46 is a first-in-class small-molecule inhibitor targeting connective tissue growth factor (CTGF), significantly disrupts the CTGF/TGF-β1 signaling axis and suppresses cancer-associated fibroblast (CAF) functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion in PDAC.

Physicochemical Properties

M.Wt 424.49
Formula C24H28N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(1-(3,4-diethoxy-5-methoxyphenyl)vinyl)-6-methoxy-2-methyl-1H-indole-7-carboxamide

References

1. Shen Y, et al. Proc Natl Acad Sci U S A. 2026 Sep 8;123(36):e2535905123.

2. Patent CN118324684 A 2024-07-12.

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