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Chemical Structure : QcrB inhibitor TB47
Catalog No.: PC-35875Not For Human Use, Lab Use Only.
QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates.
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QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates。
TB47 shows promising profiles, including negligible CYP450 interactions, cytotoxicity and hERG channel inhibition in pharmacokinetic and toxicity studies。
TB47 causes metabolic redox stress, strongly synergistic with pyrazinamide and rifampicin in mouse infection models, but not as a monotherapy.
| M.Wt | 538.571 | |
| Formula | C29H29F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lu X, et al. ACS Infect Dis. 2018 Nov 28. doi: 10.1021/acsinfecdis.8b00225.
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